How does Ozempic work? – Stimulife Health Blog

Ozempic (semaglutide) is a GLP-1 receptor agonist used to treat type 2 diabetes and aid in weight loss. It works by mimicking the glucagon-like peptide-1 (GLP-1) hormone, which plays a key role in regulating blood sugar and appetite. Here’s how it works:

1. Lowers Blood Sugar

• Increases Insulin Secretion: Ozempic stimulates the pancreas to release insulin only when blood sugar is high, helping to lower glucose levels after meals.
• Decreases Glucagon Release: It prevents the liver from producing and releasing too much glucose, reducing blood sugar spikes.

2. Slows Digestion

• Ozempic delays stomach emptying, making you feel full longer and helping with portion control.

3. Reduces Appetite & Aids Weight Loss

• It affects appetite centers in the brain, reducing hunger and food cravings, leading to less calorie intake and weight loss.

How Ozempic Helps with Weight Loss:

1. Appetite Suppression – Reduces hunger and cravings, making it easier to eat less.
2. Slower Digestion – Keeps food in your stomach longer, leading to prolonged feelings of fullness.
3. Blood Sugar Control – Helps regulate insulin levels, preventing spikes and crashes that can lead to overeating.
4. Changes in Food Preferences – Some users report losing interest in high-calorie or unhealthy foods.

How Much Weight Can You Lose?

• In clinical trials, people using semaglutide lost 10-15% of their body weight on average over a year.
• Weight loss results vary depending on diet, lifestyle, and dosage.

Side Effects to Consider:

• Common: Nausea, vomiting, diarrhea, constipation, fatigue.
• Serious (but rare): Pancreatitis, gallbladder issues, kidney problems.

Who Should Consider Ozempic?

• People with type 2 diabetes needing blood sugar control.
• Those with obesity (BMI ≥30) or overweight (BMI ≥27) with weight-related conditions.
• Not recommended for those with a history of thyroid cancer or pancreatitis.

Alternatives:

• Wegovy (higher-dose semaglutide) – Specifically FDA-approved for weight loss.
• Mounjaro (tirzepatide) – Another GLP-1 medication with strong weight loss effects.

4. Protects the Heart

• Studies show that Ozempic can lower the risk of heart disease in people with type 2 diabetes by improving blood sugar levels and promoting weight loss.

Ozempic is typically injected once a week and is often prescribed alongside diet and exercise for better results.